![]() ![]() This transgeneration effect of taurine-deficiency in the perinatal period fits into the concept of fetal origin of adult disease. The adult offspring of taurine-deficient mothers display signs of impaired neurological function, impaired glucose tolerance and vascular dysfunction they may develop gestational diabetes and transmit the effects to the next generation. ![]() Most pregnant women should consume an extra 300 calories a day, which means they also need to increase their water intake by between 300 and 450 milliliters. Taurine-deficiency in the mother leads to growth retardation of the offspring, and to impaired perinatal development of the central nervous system and of the endocrine pancreas. Water Needs During Pregnancy Adults, including pregnant women, need between 1 and 1.5 milliliters of water for each calorie consumed. Low maternal taurine levels result in low fetal taurine levels. It is accumulated especially in the fetal and neonatal brain. The primary BAs cholic (CA) and chenodeoxycholic acid (CDCA) as well as their glycine (G-) and taurine (T-) conjugates amount to nearly 70 of total BAs in serum and were not changed from the 15th to the 40th weeks of pregnancy, but free and G-CDCA increased significantly after delivery. During pregnancy, taurine accumulates in the maternal tissues, to be released in the perinatal period to the fetus via the placenta and to the newborn via the maternal milk. Whether a high taurine load alters renal function in man is unclear. An interesting aspect of this influence of taurine supplementation or depletion is that prenatal exposure will alter the response to a 5 body weight saline bolus. Apart from its role in cholesterol degradation, it acts as neurotransmitter, and has a function as osmoregulator and antioxidant in most body tissues. Thus, it appears that taurine status can alter renal hemodynamics. Taurine, a non-protein sulfur amino-acid, is the most abundant free amino-acid in the body and plays an important role in several essential biological processes. ![]()
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